Neuroprotective Effect of Ethanolic Extract of Portulaca quadrifida L. in Rotenone-Induced Locomotor Impairment in Drosophila Model and Haloperidol-Induced Catalepsy Rat Model

The neurodegenerative diseases are characterized by the depletion of neuronal physiology and death as a virtue potential oxidative stress. Parkinson’s disease is one debilitating wherein dopaminergic neurons results mainly in motor dysfunction. present study was focused to neuroprotective effect ethanolic extract Portulaca quadrifida L. (Portulacaceae) against like symptoms. experimental designs included were rotenoneinduced locomotor impairment Drosophila model haloperidol-induced catalepsy rat model; both resembling dysfunction observed clinically disease. behavioral parameters evaluated. Additionally biochemical stress markers evaluated model. behavior rotenone-exposed improved significantly (p<0.05) when treated with 1 2 mg/ml doses quadrifida. response induced rats (disease control group) lower than that vehicle standard group. co-exposed haloperidol showed marked improvement at 100 200 mg/kg body weight significant further confirmed antioxidant efficacy drug used Zandu Zandopa powder. Thus reveals imparts hence has be treatment